RepOdor is conceived with the aim to provide to the users a dynamic and flexible storage tool
in the field of olfactory receptors (ORs) and their experimentally known ligands. The goal is to complement the actual landscape of available
online resources for Olfaction with a tool that focuses on the interactions between ORs and odorants reported in the literature in the
last 30 years.
Stored information about ORs are nomenclature details, organism and sequence, meanwhile information
such as physicochemical data, structural features and pharmacological information can be found on odorant
molecules. Moreover, information about interaction between ORs and their experimentally known ligands
are stored.
Lastly, thanks to the implemented search tools based on BLASTp (for sequence-based receptor similarity)
and OpenBabel (for Tanimoto index-based odorant chemical similarity), users will have the chance to
find potentially closely related OR-odorant pairs.
Thus, RepOdor aims at being a fundamental resource for molecular characterization of OR-odorant pairs, either by reporting
already experimentally validated or suggesting new pairs for experimental testing.
RepOdor navigation
From the main page and from the other website page, below our logo, there is
all the needed to explore the website and exploit its functionalities.
The button below will bring you again to the homepage.
By clicking Odorant, you will be redirected to the complete list of odorant molecules stored in RepOdor. From there you can browse manually those data.
The section that this button will help you to reach stores experimentally data on interactions between ORs and odorants.
You can reach the detailed page about the involved OR/odorant by clicking the desired item. Where available, EC50 is present.
If you are in need of more detailed information about this binding event, you can also refer to the article.
From this page, you will be able to browse Ors data in a more specific way. There you will find two search bars, all case-insensitive.
Moreover, at the bottom of the page you can launch BlastP, with which you will be able to find the most similar receptors among the
ones stored in RepOdor.
Following the same ratio applied to the previous described page, here you can selectively look for Odorant molecules.
Specifically, two case-insensitive search bars and the possibility to launch Tanimoto Index of Similarity helps you
in narrowing your Odorant search.
By looking to the footer website, reachable from all pages, you can have other glimpses of the database. About RepOdor will bring you to this page.
For information about our institution or our group, please follow Forschügszentrum Jülich or
IAS5-INM9 Team, respectively.
Main packages used to build RepOdor functionalities:
For further information on RepOdor, please refer to the following publication:
Giuliano Santarpia, as the main author of the resource, states that the development of the online database presented herein was funded by the
Jülich-Aachen Research Alliance (JARA) and Forschungszentrum Jülich,
and was undertaken as part of the author's PhD thesis.
The database was designed to facilitate access to relevant information and support ongoing research efforts in the field.